Further investigations of the ?-chain in a Ghanaian adult, homozygous for hereditary persistence of fetal haemoglobin: Isolation of ? CB-3 peptides and G?: A? ratio determination in human Hb F

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dc.contributor.authorKamuzora, H.
dc.contributor.authorRingelhann, B.
dc.contributor.authorKonotey-Ahulu, F.I.
dc.contributor.authorLehmann, H.
dc.contributor.authorLorkin, P.A.
dc.date.accessioned2025-11-19T17:25:25Z
dc.date.issued1975
dc.description.abstractThe ?-chain in a Ghanaian homozygous for hereditary persistence of fetal haemoglobin was considered to be of the G? type on the basis of the amino acid analysis of ?Tp XIV (?133�144) of the Hb F of this subject [1]. Recently, the sequence of residues ?134�137 of the ?-chain of this subject was determined and found to contain some alanine at position ?l36. It is therefore of the G? + A? type. A rapid technique for the isolation of ?CB-3 (?l34�146) peptides in human fetal haemoglobin for G?:A? ratio determination is described. � 1975 S. Karger AG, Basel. � 2019 Elsevier B.V., All rights reserved.
dc.identifier.issn14219662
dc.identifier.issn00015792
dc.identifier.other10.1159/000208198
dc.identifier.urihttps://achimotaschoolarchives.org/handle/123456789/387
dc.language.isoen
dc.sourceActa Haematologica
dc.subjectDansyl-Edman technique
dc.subjectFetal haemoglobin
dc.subjectHaemoglobinopathies
dc.subjectHereditary persistence of Hb F
dc.subject?-chains of Hb F
dc.subjecthemoglobin F
dc.subjectpeptide fragment
dc.subjecthemoglobin f
dc.subjecthemoglobin gamma chain
dc.subjectadult
dc.subjectarticle
dc.subjectgenetics
dc.subjectGhana
dc.subjecthemoglobinopathy
dc.subjecthomozygote
dc.subjecthuman
dc.subjectinfant
dc.subjectamino acid sequence
dc.subjectclassification
dc.subjecthomozygosity
dc.subjectin vitro study
dc.subjectmethodology
dc.subjectAdult
dc.subjectFetal Hemoglobin
dc.subjectHemoglobinopathies
dc.subjectHomozygote
dc.subjectHuman
dc.subjectInfant
dc.subjectPeptide Fragments
dc.titleFurther investigations of the ?-chain in a Ghanaian adult, homozygous for hereditary persistence of fetal haemoglobin: Isolation of ? CB-3 peptides and G?: A? ratio determination in human Hb F
dc.typeArticle

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