Further investigations of the ?-chain in a Ghanaian adult, homozygous for hereditary persistence of fetal haemoglobin: Isolation of ? CB-3 peptides and G?: A? ratio determination in human Hb F
Loading...
Date
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The ?-chain in a Ghanaian homozygous for hereditary persistence of fetal haemoglobin was considered to be of the G? type on the basis of the amino acid analysis of ?Tp XIV (?133�144) of the Hb F of this subject [1]. Recently, the sequence of residues ?134�137 of the ?-chain of this subject was determined and found to contain some alanine at position ?l36. It is therefore of the G? + A? type. A rapid technique for the isolation of ?CB-3 (?l34�146) peptides in human fetal haemoglobin for G?:A? ratio determination is described. � 1975 S. Karger AG, Basel. � 2019 Elsevier B.V., All rights reserved.
Description
Keywords
Dansyl-Edman technique, Fetal haemoglobin, Haemoglobinopathies, Hereditary persistence of Hb F, ?-chains of Hb F, hemoglobin F, peptide fragment, hemoglobin f, hemoglobin gamma chain, adult, article, genetics, Ghana, hemoglobinopathy, homozygote, human, infant, amino acid sequence, classification, homozygosity, in vitro study, methodology, Adult, Fetal Hemoglobin, Hemoglobinopathies, Homozygote, Human, Infant, Peptide Fragments