The ?-chain in a ghanaian adult, homozygous for hereditary persistence of fetal haemoglobin
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Abstract
Fetal haemoglobin consists of ?- and ?-chains. There are two types of human ?-chains: One,(G?) in which residue 136 is one of glycine, and another (A?), in which that position is occupied by a residue of alanine. Some time ago a homozygote for the high persistent fetal haemoglobin gene was found in Ghana whose sole red cell pigment was fetal haemoglobin. The nature of the fetal haemoglobin in this individual has now been determined. It is entirely of the G?-type. � 1974 by S. Karger AG, Basel. � 2015 Elsevier B.V., All rights reserved.
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Keywords
Fetal haemoglobin, Haemoglobinopathies, Hereditary persistence of Hb F, ?-Chains of Hb F, hemoglobin f, hemoglobin gamma chain, biochemistry, homozygosity, major clinical study, theoretical study, Amino Acids, Cellulose, Chromatography, Electrophoresis, Paper, Fetal Hemoglobin, Ghana, Hemoglobinopathies, Homozygote, Humans, Immunoglobulin Fragments, Immunoglobulin Heavy Chains, Peptides, Trypsin