Homozygotes for the hereditary persistence of fetal hemoglobin: The ratio of G? to A? chains and biosynthetic studies

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dc.contributor.authorRingelhann, B.
dc.contributor.authorAcquaye, C.T.A.
dc.contributor.authorOldham, J.H.
dc.contributor.authorKonotey-Ahulu, F.I.
dc.contributor.authorYawson, G.
dc.contributor.authorSukumaran, P.K.
dc.contributor.authorSchroeder, W.A.
dc.contributor.authorHuisman, T.H.J.
dc.date.accessioned2025-11-19T17:25:24Z
dc.date.issued1977
dc.description.abstractTwo sons of a previously reported Ghanaian homozygote for the hereditary persistence of fetal hemoglobin (HPFH) (Ringelhann et al., 1970) also are HPFH homozygotes. In addition, another unrelated adult Ghanaian homozygote has been detected. All of these Ghanaian homozygotes as well as three American Black HPFH homozygotes have the G?A? type of HPFH with a G? to A? ratio of about 3:2, in contrast to an Asiatic Indian homozygote who has the G? type. Globin chain synthesis in HPFH homozygotes is unbalanced, with a ?/? ratio of 0.6 or less, whereas it is balanced in heterozygotes according to most reports. � 1977 Plenum Publishing Corporation. � 2019 Elsevier B.V., All rights reserved.
dc.identifier.issn15734927
dc.identifier.issn00062928
dc.identifier.other10.1007/BF00484499
dc.identifier.urihttps://achimotaschoolarchives.org/handle/123456789/380
dc.language.isoen
dc.publisherKluwer Academic Publishers-Plenum Publishers
dc.sourceBiochemical Genetics
dc.subjecthemoglobin f
dc.subjecthemoglobin gamma chain
dc.subjectdiagnosis
dc.subjectetiology
dc.subjecthemoglobin f persistence
dc.subjecthomozygote
dc.subjectin vitro study
dc.subjectmajor clinical study
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectChromatography, DEAE-Cellulose
dc.subjectFemale
dc.subjectFetal Hemoglobin
dc.subjectGhana
dc.subjectGlobins
dc.subjectHemoglobinopathies
dc.subjectHomozygote
dc.subjectHumans
dc.subjectIndia
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPedigree
dc.subjectProtein Precursors
dc.subjectUnited States
dc.titleHomozygotes for the hereditary persistence of fetal hemoglobin: The ratio of G? to A? chains and biosynthetic studies
dc.typeArticle

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