Further observations on hydrogen peroxide antisepsis and COVID-19 cases among healthcare workers and inpatients

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dc.contributor.authorAmoah, A.G.B.
dc.contributor.authorSagoe, K.W.
dc.contributor.authorQuakyi, I.A.
dc.contributor.authorAyettey-Anie, H.N.G.
dc.contributor.authorAyettey-Adamafio, M.N.B.
dc.contributor.authorAyettey Brew, R.N.A.
dc.contributor.authorNewman-Nartey, M.
dc.contributor.authorNartey, N.O.
dc.contributor.authorBrightson, K.T.C.
dc.contributor.authorKessie, G.
dc.contributor.authorAyettey, A.S.
dc.contributor.authorKonotey-Ahulu, F.I.D.
dc.date.accessioned2025-11-19T17:25:23Z
dc.date.issued2022
dc.description.abstractBackground: The use of prophylactic antisepsis to protect against coronavirus disease 2019 (COVID-19) has been suggested. This study investigated hydrogen peroxide antisepsis (HPA) at two hospitals in Ghana. Methods: Cases of COVID-19 among healthcare workers (HCWs) using hydrogen peroxide (HP-HCWs) or not using hydrogen peroxide (NHP-HCWs), vaccinated or unvaccinated, were recorded at Shai-Osudoku Hospital (SODH), Dodowa, and Mount Olives Hospital (MOH), Techiman, between May 2020 and December 2021. The effect of HPA in all inpatients at MOH was also observed. Permutation tests were used to determine P values. Findings: At SODH, there were 62 (13.5%) cases of COVID-19 among 458 NHP-HCWs but no cases among eight HP-HCWs (P=0.622) from May to December 2020. Between January and March 2021, 10 (2.7%) of 372 NHP-HCWs had COVID-19, but there were no cases among 94 HP-HCWs (P=0.206). At MOH, prior to HPA, 17 (20.2%) of 84 HCWs and five (1.4%) of 370 inpatients had COVID-19 in July 2020. From August 2020 to March 2021, two of 54 (3.7%) HCWs who stopped HPA had COVID-19; none of 32 NHP-HCWs contracted COVID-19. At SODH, none of 23 unvaccinated HP-HCWs and 35 (64%) of 55 unvaccinated NHP-HCWs had COVID-19 from April to December 2021 (P<0.0001). None of 34 vaccinated HP-HCWs and 53 (13.6%) of 390 vaccinated NHP-HCWs had COVID-19 (P=0.015). No inpatients on prophylactic HPA (total 7736) contracted COVID-19. Conclusion: Regular, daily HPA protects HCWs from COVID-19, and curtails nosocomial spread of SARS-CoV-2. � 2022 Elsevier B.V., All rights reserved.
dc.identifier.issn01956701
dc.identifier.issn15322939
dc.identifier.other10.1016/j.jhin.2022.05.007
dc.identifier.urihttps://achimotaschoolarchives.org/handle/123456789/366
dc.language.isoen
dc.publisherW.B. Saunders Ltd
dc.sourceJournal of Hospital Infection
dc.subjectAntisepsis
dc.subjectCOVID-19
dc.subjectHealthcare workers
dc.subjectHydrogen peroxide
dc.subjectMouthwash
dc.subjectNasal rinse
dc.subjectNasopharyngeal
dc.subjectOropharyngeal
dc.subjecthydrogen peroxide
dc.subjectSARS-CoV-2 vaccine
dc.subjectantisepsis
dc.subjectArticle
dc.subjectcoronavirus disease 2019
dc.subjectGhana
dc.subjecthealth care personnel
dc.subjecthospital infection
dc.subjecthospital patient
dc.subjecthuman
dc.subjectinfection prevention
dc.subjectmajor clinical study
dc.subjectobservational study
dc.subjectvaccinee
dc.subjectvirus transmission
dc.subjectprevention and control
dc.subjectAntisepsis
dc.subjectCOVID-19
dc.subjectHealth Personnel
dc.subjectHumans
dc.subjectHydrogen Peroxide
dc.subjectSARS-CoV-2
dc.titleFurther observations on hydrogen peroxide antisepsis and COVID-19 cases among healthcare workers and inpatients
dc.typeArticle

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