The origin of anaemia in tropical splenomegaly syndrome

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dc.contributor.authorRingelhann, B.
dc.contributor.authorMiller, H.
dc.contributor.authorKonotey-Ahulu, F.I.
dc.date.accessioned2025-11-19T17:25:25Z
dc.date.issued1973
dc.description.abstractThirty patients with the diagnosis of tropical splenomegaly syndrome were investigated in Ghana. The patients had low haematocrit and low WBC and platelet counts and the number of reticulocytes and indirect bilirubin were slightly increased. Red cell survival and radioiron studies showed slight haemolysis. IgM immunoglobulin was increased. RBC volume measured with 51Cr tagged erythrocytes was normal but plasma volume assayed with 125I labelled serum albumin was increased. Heat damaged and 51Cr labelled red cells were used to study microcirculation in the spleen. It was concluded that the low haematocrit was due to the increased plasma volume and the temporary RBC sequestration in the large spleen. In addition, there is a compensated haemolysis. � 2004 Elsevier B.V., All rights reserved.; Medline is the source for the MeSH terms of this document.
dc.identifier.issn15989
dc.identifier.urihttps://achimotaschoolarchives.org/handle/123456789/393
dc.language.isoen
dc.sourceActa Medica Academiae Scientiarum Hungaricae
dc.subjectalbumin i 125
dc.subjectbilirubin
dc.subjectchromium 51
dc.subjectimmunoglobulin m
dc.subjectanemia
dc.subjectethnic or racial aspects
dc.subjectetiology
dc.subjecthematocrit
dc.subjecthemolysis
dc.subjecthistology
dc.subjectleukocyte
dc.subjectleukocyte count
dc.subjectpathology
dc.subjectplasma volume
dc.subjectradioactive iron
dc.subjectreticulocyte
dc.subjectsplenomegaly
dc.subjectthrombocyte
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAnemia
dc.subjectBilirubin
dc.subjectChromium Radioisotopes
dc.subjectErythrocyte Count
dc.subjectFemale
dc.subjectHematocrit
dc.subjectHemolysis
dc.subjectHuman
dc.subjectIron Radioisotopes
dc.subjectLeukocyte Count
dc.subjectLiver
dc.subjectMalaria
dc.subjectMale
dc.subjectMiddle Age
dc.subjectPlasma Volume
dc.subjectReticulocytes
dc.subjectSpleen
dc.subjectSplenomegaly
dc.subjectSyndrome
dc.subjectTropical Medicine
dc.titleThe origin of anaemia in tropical splenomegaly syndrome
dc.typeArticle

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